Six Supernutrients That Can Transform Your Health

Imagine sustained energy… a flawless memory… perfect vision and hearing… and the physical endurance of someone half your age—all as you reach fifty, sixty, seventy and beyond.

This may sound like an unreachable fantasy. But there’s no rule that says your health has to fall apart once you reach middle age—especially not when a carefully chosen combination of the right phytonutrients can provide you with comprehensive protection against all of the most common pitfalls of aging …and add years of vitality onto your life in the process.

Take turmeric, for example: This is the spice that gives curry its kick—but it’s also a clinically proven antioxidant powerhouse. Turmeric—and more specifically its primary constituent curcumin—has been tested with great success against of number of inflammation-related conditions, including psoriasis, chronic pancreatitis, inflammatory bowel and eye diseases plus rheumatoid arthritis.1

Green tea is another powerful life-extending nutrient—rich in a number of health-promoting polyphenols, including the powerful antioxidant epigallocatechin-3-gallate (EGCG). Extensive research shows that, among other benefits, green tea can help to balance blood sugar and insulin levels, fight inflammation, protect against stroke-related brain damage and increase cognitive function plus help to prevent atherosclerosis resulting from elevated LDL cholesterol.2-8

Grape seed extract is a good source of a class of phytochemicals called proanthocyanidins and has emerged as another key anti-aging staple. Studies show that this antioxidant compound can support healthy blood pressure and cholesterol levels, reduce plaque-causing lipid peroxidation, inhibit clot-forming platelet aggregation and reduce inflammation.9-11 Other notable benefits of grape seed supplementation include accelerating wound healing and supporting skin health.12-13

As the most popular staple of the “French paradox”—that is, the phenomenon of low rates of coronary artery disease paired with a diet rich in saturated fat—there seems to be no limit to the health benefits of red wine… especially where your heart is concerned. Not only is it packed with both polyphenols and stilbenes—powerful antioxidants that can raise “good” cholesterol and protect against artery damage—- it’s also rich in the anti-aging compound resveratrol. Research shows that resveratrol can mimic the beneficial effects of caloric restriction—including improved heart function and bone density, better motor function, delayed cataracts and longer lifespan—without strict dieting.14-19

Your liver is your body’s filter, responsible for pushing out damaging toxins on a daily basis—so keeping this organ in perfect shape is another crucial aspect of longevity. Luckily, numerous clinical trials offer compelling modern-day support for the historical use of milk thistle—and more specifically, its main constituent silymarin—for this very purpose. Research shows that daily silymarin supplementation can improve recovery time dramatically in patients with acute hepatitis, cirrhosis, and other forms of liver disease—while additional studies indicate that it can help to maintain healthy blood sugar and offer critical protection against damaging UV radiation.20-23

Finally, the last few decades have seen the ancient herb Ginkgo biloba emerge as a superstar in the supplement world—most notably for its clinically proven benefits to nerve and cognitive health. Extensive research shows that it can increase blood flow to the brain, reduce memory deficit in Alzheimer’s patients and boost vision.24-25

References:

1. Hsu CH, Cheng AL. Clinical studies with curcumin. Adv Exp Med Biol. 2007;595:471-480.

2. Tsuneki H, Ishizuka M, Terasawa M, Wu JB, Sasaoka T, Kimura I. Effect of green tea on blood glucose levels and serum proteomic patterns in diabetic (db/db) mice and on glucose metabolism in healthy humans. BMC Pharmacol, 2004 Aug 26;4(1):18.

3. Lee H, Bae JH, Lee SR. Protective effect of green tea polyphenol EGCG against neuronal damage and brain edema after unilateral cerebral ischemia in gerbils. J Neurosci Res, 2004 Sep 15;77(6):892-900.

4. Kim HK, Kim M, Kim S, Kim M, Chung JH. Effects of green tea polyphenol on cognitive and acetylcholinesterase activities. Biosci Biotechnol Biochem, 2004 Sep;68(9):1977-9.

5. Hussain T, Gupta S, Adhami VM, Mukhtar H. Green tea constituent epigallocatechin-3-gallate selectively inhibits COX-2 without affecting COX-1 expression in human prostate carcinoma cells. Int J Cancer, 2004 Sep 28 [Epub ahead of print].

6. Pezzato E, Sartor L, Dell’aica I, Dittadi R, Gion M, Belluco C, Lise M, Garbisa S. Prostate carcinoma and green tea: PSA-triggered basement membrane degradation and MMP-2 activation are inhibited by (-)epigallocatechin-3-gallate.Int J Cancer, 2004 Dec 10;112(5):787-92.

7. Zhang M, Lee AH, Binns CW, Xie X. Green tea consumption enhances survival of epithelial ovarian cancer. Int J Cancer, 2004 Nov 10;112(3):465.

8. Ouyang P, Peng WL, Lai WY, Xu AL. [Green tea polyphenols inhibit low-density lipoprotein-induced proliferation of rat vascular smooth muscle cells] [Article in Chinese]. Di Yi Jun Yi Da Xue Xue Bao, 2004 Sep;24(9):975-9.

9. Edirisinghe I, Burton-Freeman B, Tissa Kappagoda C. Mechanism of the endothelium-dependent relaxation evoked by a grape seed extract. Clin Sci (Lond). 2008 Feb;114(4):331-7.

10. Freedman JE, Parker C, Li L, et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation. 2001;103:2792-8.

11. Shafiee M, Carbonneau MA, Urban N, Descomps B, Leger CL. Grape and grape seed extract capacities at protecting LDL against oxidation generated by Cu2+, AAPH or SIN-1 and at decreasing superoxide THP-1 cell production. A comparison to other extracts or compounds. Free Radic Res. 2003 May;37(5):573-84.

12. Katiyar SK. Dietary grape seed proanthocyanidins inhibit photocarcinogenesis through prevention of UV-induced suppression of immune responses via induction of interleukin-12 in mice. Presented at the 233rd national meeting of the American Chemical Society, Chicago, March 25, 2007. Abstract: AGFD 011.

13. Hughes-Formella B, Wunderlich O, Williams R. Anti-inflammatory and skin-hydrating properties of a dietary supplement and topical formulations containing oligomeric proanthocyanidins. Skin Pharmacol Physiol. 2007;20(1):43-9. Epub 2006 Oct 11.

14. Baur JA, Pearson KJ, Price NL, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006 Nov 16;444(7117):337-342.

15. Lagouge M, Argmann C, Gerhart-Hines Z, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 2006 Dec 15;127(6):1109-1122.

16. Pfluger PT, Herranz D, Velasco-Miguel S, Serrano M, Tschöp MH. Sirt1 protects against high-fat diet-induced metabolic damage. Proc Natl Acad Sci USA. 2008;105(28):9793-9798.

17. Sun C, Zhang F, Ge X, et al. SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell Metab 2007;6:307-319.

18. Pearson KJ, Baur JA, Lewis KN, et al. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab. 2008 Aug;8(2):157-168.

19. Barger JL, Kayo T, Vann JM, et al. A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. PLoS ONE. 2008 Jun 4;3(6):e2264.

20. El-Kamary SS, Shardell MD, Abdel-Hamid M, Ismail S, El-Ateek M, Metwally M, Mikhail N, Hashem M, Mousa A, Aboul-Fotouh A, El-Kassas M, Esmat G, Strickland GT. A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms, signs and biomarkers of acute hepatitis. Phytomedicine. 2009 May;16(5):391-400.

21. Huseini HF, Larijani B, Heshmat R, Fakhrzadeh H, Radjabipour B, Toliat T, Raza M. The efficacy of Silybum marianum (L.) Gaertn. (silymarin) in the treatment of type II diabetes: a randomized, double-blind, placebo-controlled, clinical trial. Phytotherapy Research. Published online ahead of print on October 30, 2006.

22. Meeran SM, Katiyar S, Elmets CA, Katiyar SK. Silymarin inhibits UV radiation-induced immunosuppression through augmentation of interleukin-12 in mice. Mol Cancer Ther. 2006 Jul;5(7):1660-8.

23. Svobodova A, Zdarilova A, Maliskova J, Mikulkova H, Walterova D, Vostalova J. Attenuation of UVA-induced damage to human keratinocytes by silymarin. J Dermatol Sci. 2007 Apr;46(1):21-30. Epub 2007 Feb 7.

24. B. Hofferberth. The Efficacy of EGb 761 (Ginkgo biloba extract) in Patients with Senile Dementia of the Alzheimer Type, A double-Blind, Placebo-Controlled Study on Different Levels of Investigation. Human Psychopharmacol 1994, vol. 9, 215-222.

25. Wu ZM, Yin XX, Ji L, Gao YY, Pan YM, Lu Q, Wang JY. Ginkgo biloba extract prevents against apoptosis induced by high glucose in human lens epithelial cells. Acta Pharmacol Sin. 2008 Sep;29(9):1042-50.

News Release
Herbal Science Organization Clarifies New Ginkgo Study

(Austin, TX) December 28, 2009. New research findings published this week on a standardized Ginkgo biloba extract are very limited and the public should focus on the well-documented cognitive and cardiovascular benefits of ginkgo, said the American Botanical Council (ABC), an independent nonprofit research and education organization.

A new study of previously published data being published in this week’s issue of the Journal of the American Medical Association (JAMA) has reported that a leading ginkgo extract did not reduce the decline in cognitive impairment in older adults.1,2

“There are many significant limitations of this study”, said Mark Blumenthal, ABC founder and executive director.

First, the data being published this week are drawn from a previous clinical trial which was not designed to determine the decline in cognition.3 Second, about 40% of the subjects dropped out over the 6-year duration of the trial; the statistics reported in the study include the dropouts for which no final data are available. Further, the subjects in the study were not monitored for certain cognitive parameters until several years after the trial began, creating difficulty in determining accurately whether they experienced a decline in cognition or not. Also, the age of the subjects is quite advanced, at an average of 79 years at the beginning of the trial. This age group is not typical of the age of both healthy people and those with mild cognitive impairment who use ginkgo for improving mental performance.

Further, ABC noted that another weakness of this trial is the lack of an active control, i.e., a potential third arm of the trial (i.e., besides the patients on ginkgo or placebo) in which patients would have used a pharmaceutical medication with presumed efficacy, to determine to what extent the particular population being tested would respond. This was not possible for this trial since no conventional pharmaceutical drug has ever demonstrated the ability to prevent the onset of dementia or diminish its progression.

ABC also stated that several recent publications have demonstrated an improvement in cognitive performance in subjects using the same German gingko extract.4,5,6

The new publication, by Beth E. Snits, Ph.D., a neuropsychologist associated with the University of Pittsburgh, and other colleagues, analyzed outcomes from the Ginkgo Evaluation of Memory study (GEM, published in 2008 in JAMA) to determine if ginkgo extract slowed cognitive decline in older adults who had either normal cognition or mild cognitive impairment at the beginning of the study. 3

The GEM study previously found that ginkgo extract was not effective in reducing the incidence of Alzheimer dementia or dementia overall. This large, randomized, double-blind, placebo-controlled, multi-centered clinical trial included 3,069 community-dwelling subjects (aged 72 to 96 years) who received either a dose of 120 mg of ginkgo extract twice daily or an identical-appearing placebo. The trial was conducted at 6 academic medical centers in the United States between 2000 and 2008, with a median follow-up of 6.1 years. Change in cognitive function was evaluated by various tests and measures.

ABC emphasized that the original GEM trial was designed to determine whether taking ginkgo would prevent the onset of dementia. What this new publication has done is attempted to analyze the possible decline in levels of cognitive function – not a primary outcome measure of the GEM study.

“This trial is not conclusive nor should it in any way detract from ginkgo’s reputation as a useful dietary supplement to help support and improve cognitive function and enhance peripheral circulation – conditions for which it has been reported to be effective in numerous clinical trials,” reminded Blumenthal.

At least 16 controlled clinical trials have evaluated various ginkgo extracts for healthy, non-cognitively impaired adults. A systematic review has shown that in 11 of these trials, the ginkgo increased short-term memory, concentration and time to process mental tasks.7

“The results of this new trial must be viewed in proper perspective,” noted Blumenthal. “There is a vast body of pharmacological and clinical research supporting numerous health benefits for ginkgo extracts, particularly for improving various symptoms and conditions associated with declining cognitive performance and poor circulation.”

ABC also emphasized that this publication, and the one published in 2008 on which it is based, both underscore the relative safety of ginkgo extract: the amount of adverse events were basically the same in both the ginkgo and placebo groups, particularly no serious adverse effects, e.g. no statistically significant incidence of coronary heart disease, stroke of any type, and major bleeding.

The trial utilized EGb 761®, the world’s most clinically tested ginkgo extract, produced by W. Schwabe Pharmaceuticals in Karlsruhe, Germany.

About Ginkgo Extract

Ginkgo (Ginkgo biloba) is the world’s oldest living tree, dating back about 250 million years. Ginkgo leaves have been used in traditional Chinese medicine for about 500 years. For about the past 30 years the leaves of ginkgo have been made into a highly concentrated (50:1) extract, chemically standardized to compounds unique to ginkgo (ginkgolides and bilobalide) as well as other compounds. The leading German ginkgo extract has been subjected to a vast range of clinical trials documenting its ability to improve peripheral circulation and cognitive function, particularly in patients with early stages of mild cognitive impairment, senile dementia, Alzheimer’s disease, and memory loss. Clinical trials also support the use of ginkgo extract in assisting elderly patients in walking longer distances without leg pain (peripheral arterial occlusive disease, also known as intermittent claudication). Standardized ginkgo extracts are approved for use as medicines in Germany and numerous other countries.

About the American Botanical Council

Founded in 1988 the American Botanical Council is a leading international nonprofit organization addressing research and educational issues regarding herbs and medicinal plants. ABC’s members include academic researchers and educators, universities and libraries, health professionals and medical institutions, botanical gardens and arboreta, government agencies, members of the herb, dietary supplement, cosmetic, and pharmaceutical industries, journalists, consumers, and other interested parties from over 70 countries. The organization occupies a historic 2.5-acre site in Austin, Texas where it publishes the quarterly journal HerbalGram, the monthly e-publication HerbalEGram, HerbClips (over 4000 summaries of scientific and clinical publications), reference books, and other educational materials. ABC also hosts HerbMedPro, a powerful herbal database, covering scientific and clinical publications on more than 220 herbs.

ABC is tax-exempt under section 501© (3) of the IRS Code. Information: Contact ABC at P.O. Box 144345, Austin, TX 78714-4345, Phone: 512-926-4900. Website: http://www.herbalgram.org/.

References

1. Snitz BE, O’Meara ES, Carlson MC, Arnold A, Ives DG, Rapp SR, Saxton J, Lopez OL, Dunn LO, Sink K, DeKosky ST. Does Ginkgo biloba slow cognitive decline in older adults? JAMA Dec 23/30, 2009.

2. American Medical Association. Ginkgo Biloba Does Not Appear to Slow Rate of Cognitive Decline. [press release]. Chicago, IL: Dec. 23, 2009.

3. DeKosky ST, Williamson JD, Fitzpatrick AL, et al. Ginkgo biloba for prevention of dementia: a randomized controlled trial.[see comment]. JAMA. Nov 19 2008;300(19):2253-2262.

4. QWiG Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen. IQWiG Reports – Commission No. A05-19B. Ginkgo in Alzheimer’s disease. Executive Summary. Cologne: IQWiG, 2008.

5. Kaschel R. Ginkgo biloba: specificity of neuropsychological improvement – a selective review in search of differential effects. Human Psychopharmacology: Clinical and Experimental 2009;24:345-370.

6. Kasper S, Schubert H. Ginkgo-Spezialextrakt EGb 761® in der Behandlung der Demenz: Evidenz für Wirksamkeit und Verträglichkeit. [Ginkgo biloba extract EGb 761® in the treatment of dementia: evidence of efficacy and tolerability.] Fortschritte Neurologie Psychiatrie 2009;77:494-506.

7. Crews W, Harrison DW, Griggin ML, Falwell KD, Crist T, Longest L, Hehemann L, Rey ST. The neuropsychological efficacy of ginkgo preparations in healthy and cognitively intact adults; A comprehensive review. HerbalGram 2005;67:42-62.

Source: American Botanical Council 12/30/09.